3-(4-甲基哌嗪-4-鎓-1-基)-3-氧代丙酸酯合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=45°C; Catalytic hydrogenation; cyclization; P=2327.17 Torr;
参考文献
Patino-Molina, Rosario; Herranz, Rosario; Garcia-Lopez, M. Teresa; Gonzalez-Muniz, Rosario
Tetrahedron, 1999 , vol. 55, # 52 p. 15001 - 15010
反应条件
sodium cyanoborohydride; acetic acid in methanol T=0 - 20°C;
参考文献
MERCK and CO., INC.
Patent: WO2004/83173 A2, 2004 ;
Location in patent: Page 36 ;
WO 2004/083173 A2
反应条件
1: tetrahydrofuran / 1 h / 20 °C 2: tetrahydrofuran / 18 h / 20 °C 3: 96 percent / H2 / Pd-C / ethanol / 45 °C / 2327.17 Torr View Scheme
参考文献
Patino-Molina, Rosario; Herranz, Rosario; Garcia-Lopez, M. Teresa; Gonzalez-Muniz, Rosario
Tetrahedron, 1999 , vol. 55, # 52 p. 15001 - 15010
