3-氰基-4-异丙氧基苯甲酸合成路线 （共 12 条）
反应条件
1: With ethanol; sodium hydroxide in tetrahydrofuran T=20°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Exelixis, Inc.
Patent: US2010/249071 A1, 2010 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: With water; lithium hydroxide hydrate in 1,4-dioxane T=30°C; 1.5 h; 2: With hydrogenchloride in 1,4-dioxane; water T=20°C;
参考文献
WO2011/5290 A1, ;
Page/Page column 52 ;
WO 2011/005290 A1
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C 2.1: 1-methyl-pyrrolidin-2-one / 16 h / 200 °C 3.1: water; lithium hydroxide hydrate / 1,4-dioxane / 1.5 h / 30 °C 3.2: 20 °C View Scheme
参考文献
WO2011/5290 A1, ;
WO 2011/005290 A1
反应条件
1: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere 3: sodium hydroxide / methanol / 16 h / 20 °C View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1: iodine cloride; acetic acid / 20 - 65 °C 2: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere 4: sodium hydroxide / methanol / 16 h / 20 °C View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1: potassium carbonate / acetonitrile / Reflux 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 120 °C / Inert atmosphere 3: sodium hydroxide / methanol / 16 h / 20 °C View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1.1: toluene-4-sulfonic acid / 80 - 90 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice 2.2: 16 h / 50 °C 3.1: sodium hydroxide; water / isopropyl alcohol / 20 °C 3.2: pH ~ 2 View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 120 °C / Inert atmosphere 2: sodium hydroxide / methanol / 16 h / 20 °C View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice 1.2: 16 h / 50 °C 2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C 2.2: pH ~ 2 View Scheme
参考文献
WO2011/72488 A1, ;
WO 2011/072488 A1
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 16 h / 200 °C 2.1: water; lithium hydroxide hydrate / 1,4-dioxane / 1.5 h / 30 °C 2.2: 20 °C View Scheme
参考文献
WO2011/5290 A1, ;
WO 2011/005290 A1
