6-甲基-2-(4-甲基苯基)咪唑[1,2-a]吡啶-3-乙酸甲酯合成路线 （共 4 条）
反应条件
thionyl chloride in methanol T=0°C; 2 h;
参考文献
SEPRACOR, INC.; FANG, Kevin; GROVER, Paul; JERUSSI, Tom
Patent: WO2005/44818 A2, 2005 ;
Location in patent: Page/Page column 42-43 ;
WO 2005/044818 A2
反应条件
1: With sulfuric acid T=5 - 20°C; 4 h; Heating / reflux; 2: With sodium carbonate in water pH=8; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: EP1259509 B1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
in acetonitrile 2 h; Heating / reflux;
参考文献
FERRER INTERNACIONAL, S.A.
Patent: EP1803722 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
EP 1803722 A1
反应条件
in methanol T=-5 - 40°C; 48 - 240 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: EP1259509 B1, 2005 ;
Location in patent: Page/Page column 9-10 ;
