4-氨基-2,6-二氯吡啶合成路线 （共 48 条）
反应条件
1: trifluoroacetic acid / benzene / 21 h / 90 °C 2: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme
参考文献
ChemMedChem, , vol. 8, # 6 p. 967 - 975
反应条件
potassium permanganate; ammonia; KNH2 1.) DME, -70 deg C, 2.) DME, -70 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 56, # 11.1 p. 2313 - 2325
反应条件
1.1: triethylamine / dichloromethane / Cooling with ice 2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -70 - -60 °C / Inert atmosphere 2.2: -70 - 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; ATKINSON, Francis Louis; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander George Steven; WILSON, David Matthew
Patent: WO2011/134971 A1, 2011 ;
WO 2011/134971 A1
反应条件
in ethanol T=150°C; 6 h;
参考文献
Liu, Gang; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Liu, Mei
Patent: US2006/173050 A1, 2006 ;
Location in patent: Page/Page column 38; 63 ;
US 20060173050 A1
反应条件
sodium ethanolate T=150°C;
参考文献
Woods, Keith W.; Lai, Chunqiu; Miyashiro, Julie M.; Tong, Yunsong; Florjancic, Alan S.; Han, Edward K.; Soni, Niru; Shi, Yan; Lasko, Loren; Leverson, Joel D.; Johnson, Eric F.; Shoemaker, Alexander R.; Penning, Thomas D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1940 - 1943
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=29°C; 3 h;
参考文献
Liu, Yahua; Ding, Qiang; Wu, Xu
Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 6025 - 6028
反应条件
1: 0.5 h / 150 °C / |Microwave irradiation 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 6 h / 100 °C 3: tert.-butylnitrite; copper dichloride / acetonitrile / 40 - 80 °C View Scheme
参考文献
HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd
Patent: US2013/158042 A1, 2013 ;
反应条件
1: 0.5 h / 150 °C / |Microwave irradiation 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 6 h / 100 °C 3: tert.-butylnitrite; copper dichloride / acetonitrile / 40 - 80 °C 4: sodium hydroxide; water / methanol / 12 h / 20 °C View Scheme
参考文献
HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd
Patent: US2013/158042 A1, 2013 ;
反应条件
sulfuric acid; nitric acid T=0°C; 2 h;
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
反应条件
1.1: hydrochloric acid; sodium nitrite / acetonitrile; H2O / 0.08 h / cooling 1.2: 52 percent / potassium iodide / acetonitrile; H2O 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: zinc chloride / tetrahydrofuran; hexane / 0.25 h 2.3: 98 percent / tetrakis(triphenylphosphine)palladium(0) / tetrahydrofuran; hexane / 16 h / Heating View Scheme
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
