4-氨基-2,6-二氯吡啶合成路线 （共 48 条）
反应条件
1: concentrated aqueous hydrochloric acid / Durchleiten von Chlorwasserstoff und Behandeln der Reaktionsloesung mit Natriumnitrit 2: methanol 3: phosphorus (V)-chloride View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
sulfuric acid; copper(II) sulfate; sodium nitrite Diazotization.Reagens 4: Kupfer-Pulver;
参考文献
Talik; Plazek
Roczniki Chemii, 1959 , vol. 33, p. 387,392
Chem.Abstr., 1959 , p. 18954
反应条件
1.1: aq. HCl / 24 h / 20 °C 1.2: 57 percent / aq. NaNO2; aq.KI / 0.08 h 2.1: 98 percent / Pd(PPh3)4 / tetrahydrofuran; various solvent(s) / 4 h 3.1: 95 percent / NaH / dimethylformamide; various solvent(s) / 4 h / 90 °C 4.1: H2 / Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
反应条件
1: With hydrogenchloride T=20°C; 24 h; 2: With potassium iodide; sodium nitrite 0.0833333 h; Further stages.;
参考文献
The Regents of the University Of California
Patent: WO2004/46103 A2, 2004 ;
Location in patent: Page 33-34; 39-40 ;
反应条件
1: With sulfuric acid T=-5°C; 2: With nitric acid in water T=0 - 80°C; 3: With ammonia in water pH=~ 4; Cooling with acetone-dry ice;
参考文献
LIGAND PHARMACEUTICALS INC.; COLE, Andrew; MCGUINNESS, Brian, F.; SHAO, Yuefei; DONG, Guizhen; HENDERSON, Ian
Patent: WO2010/8775 A1, 2010 ;
Location in patent: Page/Page column 24 ;
WO 2010/008775 A1
反应条件
sulfuric acid; copper(II) sulfate; potassium bromide; sodium nitrite T=60°C; Diazotization.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser;
参考文献
MERCK and CO., INC.
Patent: WO2007/21710 A1, 2007 ;
Location in patent: Page/Page column 42 ;
WO 2007/021710 A1
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h 2.1: potassium fluoride; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane / dimethyl sulfoxide / 72 h / 160 °C 2.2: 1 h View Scheme
参考文献
BRACCO IMAGING S.P.A.; SWENSON, Rolf, E.; RAJU, Natarajan; ESTRELLA-JIMENEZ, Maria, E.; RAMALINGAM, Kondareddiar
Patent: WO2011/159864 A1, 2011 ;
反应条件
sodium methylate 72 h; Reflux;
参考文献
AMGEN INC.; DU, Xiaohui; FU, Zice; HOUZE, Jonathan, B.; JIAO, Xianyun; KIM, Yong-jae; LI, Leping; LIU, Jinqian; LIZARZABURU, Mike; MEDINA, Julio; SHEN, Wang; TURCOTTE, Simon; YU, Ming
Patent: WO2010/93849 A2, 2010 ;
Location in patent: Page/Page column 126 ;
WO 2010/093849 A2
反应条件
1: HNO3; H2SO4 / 20 °C 2: H2SO4 / 100 °C 3: 51 percent / Fe / 2 h / Heating 4: aq. NaOH / Heating View Scheme
参考文献
GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J
Patent: WO2012/123312 A1, 2012 ;
WO 2012/123312 A1
反应条件
TEA in benzene 5 h; Heating;
参考文献
De Vita, Daniela; Scipione, Luigi; Tortorella, Silvano; Mellini, Paolo; Di Rienzo, Barbara; Simonetti, Giovanna; D'Auria, Felicia Diodata; Panella, Simona; Cirilli, Roberto; Di Santo, Roberto; Palamara, Anna Teresa
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 334 - 342
