1,2,3,4,6-D-葡萄糖五乙酸酯合成路线 （共 84 条）
反应条件
caesium carbonate; acetic acid; hydrazine in dichloromethane; N,N-dimethyl-formamide T=20 - 50°C; imidation; 1.8 h; Product distribution; Further Variations:ReagentsSolventsTemperaturestime;
参考文献
Dumont-Hornebeck, Beatrice; Joly, Jean-Pierre; Coulon, Joel; Chapleur, Yves
Carbohydrate Research, 1999 , vol. 320, # 3-4 p. 147 - 160
反应条件
1: hydrogen bromide; acetic acid 2: ammonium cerium (IV) nitrate; sodium azide 3: lithium bromide 4: Ag2CO3; silver perchlorate 5: acetic acid; zinc 6: trifluoroacetic acid / methoxybenzene View Scheme
参考文献
Cai, Hui; Huang, Zhi-Hua; Shi, Lei; Zou, Peng; Zhao, Yu-Fen; Kunz, Horst; Li, Yan-Mei
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3685 - 3689
反应条件
trimethylsilylazide; tin(IV) chloride in hexane; dichloromethane; ethyl acetate
参考文献
Alchemia Pty LTD
Patent: US6573337 B1, 2003 ;
反应条件
1: hydrogen bromide; acetic acid 2: ammonium cerium (IV) nitrate; sodium azide 3: lithium bromide 4: Ag2CO3; silver perchlorate 5: acetic acid; zinc 6: trifluoroacetic acid / methoxybenzene View Scheme
参考文献
Cai, Hui; Huang, Zhi-Hua; Shi, Lei; Zou, Peng; Zhao, Yu-Fen; Kunz, Horst; Li, Yan-Mei
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3685 - 3689
反应条件
1: acetic anhydride; hydrogen bromide; acetic acid / dichloromethane / 20 °C 2: acetone / |Reflux View Scheme
参考文献
Jayasundara, Dilushan R.; Duff, Thomas; Angione, M. Daniela; Bourke, Jean; Murphy, Deirdre M.; Scanlan, Eoin M.; Colavita, Paula E.
Chemistry of Materials, 2013 , vol. 25, # 20 p. 4122 - 4128
反应条件
1: acetic anhydride; hydrogen bromide; acetic acid / dichloromethane / 20 °C 2: acetone / |Reflux View Scheme
参考文献
Jayasundara, Dilushan R.; Duff, Thomas; Angione, M. Daniela; Bourke, Jean; Murphy, Deirdre M.; Scanlan, Eoin M.; Colavita, Paula E.
Chemistry of Materials, 2013 , vol. 25, # 20 p. 4122 - 4128
反应条件
1: acetic anhydride; hydrogen bromide; acetic acid / dichloromethane / 20 °C 2: acetone / |Reflux View Scheme
参考文献
Jayasundara, Dilushan R.; Duff, Thomas; Angione, M. Daniela; Bourke, Jean; Murphy, Deirdre M.; Scanlan, Eoin M.; Colavita, Paula E.
Chemistry of Materials, 2013 , vol. 25, # 20 p. 4122 - 4128
反应条件
1: boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C
2: sodium methylate; methanol
3: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
4: N-iodo-succinimide; water / acetone
5: acetic anhydride; dimethyl sulfoxide / 20 °C
View Scheme
参考文献
Lambu, Mallikharjuna Rao; Hussain, Altaf; Sharma, Deepak K.; Yousuf, Syed Khalid; Singh, Baldev; Tripathi, Anil. K.; Mukherjee, Debaraj
RSC Advances, 2014 , vol. 4, # 22 p. 11023 - 11028
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=20°C; 4 h;
参考文献
Schottelius, Margret; Reubi, Jean Claude; Eltschinger, Veronique; Schwaiger, Markus; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2778 - 2789
反应条件
1.1: dichloromethane / 0.5 h / 0 °C
1.2: 5 h / 20 °C
2.1: sodium methylate; methanol / 2 h / pH 9
3.1: 1 h / 20 °C / |Molecular sieve; |Inert atmosphere
3.2: 2 h / -30 °C / |Molecular sieve; |Inert atmosphere
View Scheme
参考文献
Meng, Bo; Zhu, Zhenqian; Baker, David C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 28 p. 5182 - 5191
