1: toluene / Heating 2: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C 3: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h View Scheme

1: 79 percent / acetonitrile / 48 h / 20 °C 2: NaH / tetrahydrofuran / Heating 3: 274 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 4: 87 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme

1: toluene / Heating 2: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C 3: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / pyridine / 2 h / 20 &deg;C<br />2: 75 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 6 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / pyridine / 2 h / 20 &deg;C<br />2: 75 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 6 h / 20 &deg;C<br /> <br /> &nbsp;