2-甲氧基-5-甲基-4(1H)-嘧啶酮合成路线 （共 9 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=25°C; 3 h;
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
反应条件
calcium hydroxide powder in water T=20°C; Cyclization; 24 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
triethylamine in tetrahydrofuran T=25°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
反应条件
1: molecular sieves 4 Angstroem / toluene / 1.5 h / 25 °C 2: Et3N / tetrahydrofuran / 5 h / 25 °C 3: 98 percent / NH3 / methanol / 0 °C 4: 35 percent / NaH / dimethylformamide / 3 h / 25 °C View Scheme
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
反应条件
1: Et3N / tetrahydrofuran / 5 h / 25 °C 2: 98 percent / NH3 / methanol / 0 °C 3: 35 percent / NaH / dimethylformamide / 3 h / 25 °C View Scheme
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
反应条件
1: 98 percent / NH3 / methanol / 0 °C 2: 35 percent / NaH / dimethylformamide / 3 h / 25 °C View Scheme
参考文献
Perez, Caroline; Janin, Yves L.; Adams, David R.; Monneret, Claude; Grierson, David S.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 901 - 911
反应条件
1: 96 percent / LiH / dioxane / 1 h / 20 °C 2: 96 percent / aq. HCl / dioxane / 2 h / 60 °C View Scheme
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
1: 27 percent / LiH / dioxane / 24 h / 60 °C
2: 96 percent / aq. NaOH / dioxane
View Scheme
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
lithium hydride in 1,4-dioxane
T=60°C; Alkylation; demethylation; 24 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
