2-氯-1,3-苯并噻唑-6-醇合成路线 （共 5 条）
反应条件
1: With AlCl3, aluminium chloride in toluene T=110°C; 1 h; 2: With hydrogenchloride; water in toluene T=20°C;
参考文献
CRITICAL THERAPEUTICS, INC.
Patent: WO2007/146066 A2, 2007 ;
Location in patent: Page/Page column 91 ;
反应条件
sodium hydroxide; trimethylsilyl iodide in methanol; chloroform; water
参考文献
Boehringer Mannheim GmbH
Patent: US4826989 A1, 1989 ;
反应条件
potassium carbonate in N-methyl-acetamide; water
参考文献
Dr. Karl Thomae GmbH
Patent: US5919807 A1, 1999 ;
反应条件
sodium hydroxide; xylene
参考文献
Utsumi et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 238,240
Chem.Abstr., 1955 , p. 3163
反应条件
1: NaOH; xylene
2: methanol
View Scheme
参考文献
Utsumi et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 238,240
Chem.Abstr., 1955 , p. 3163
