5-苄基-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮合成路线 （共 6 条）
参考文献
Shionogi and Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru
Patent: EP2604260 A1, 2013 ;
Location in patent: Paragraph 0346; 0348 ;
反应条件
hydrogenchloride; sodium Multistep reaction;
参考文献
Orr, G. Faye; Musso, David L.
Synthetic Communications, 1996 , vol. 26, # 1 p. 179 - 189
反应条件
1: sodium hydride / mineral oil; ethylene glycol dimethyl ether / 18 h / 20 °C 2: sodium methylate / methanol / 17 h / |Reflux View Scheme
参考文献
Shionogi and Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru
Patent: EP2604260 A1, 2013 ;
反应条件
1: 90 percent / aq. NaOH / ethanol / 60 °C 2: 64 percent / 5 h / 140 - 150 °C View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
反应条件
acetic acid; chloroacetic acid
18 h; Heating;
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
1: 80 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating
2: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h
3: NH3(g) / methanol / 18 h / Ambient temperature
View Scheme
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
