N-boc-4-氟甲基哌啶合成路线 （共 3 条）
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in tetrahydrofuran; dichloromethane T=0 - 20°C; 17 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
tetraethyl ammonium fluoride in acetonitrile T=70°C; Fluorination; 6 h;
参考文献
Gilissen; Bormans; De Groot; Verbruggen
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 13 p. 1289 - 1300
反应条件
2: 37.8 percent / triethylamine / CH2Cl2 3: 78 percent / tetraethylammonium fluoride dihydrate / acetonitrile / 6 h / 70 °C View Scheme
参考文献
Gilissen; Bormans; De Groot; Verbruggen
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 13 p. 1289 - 1300
