1.1: 90 percent / CH3SO2Cl; Et3N / CH2Cl2 / 0 - 20 °C 2.1: 91 percent / H2O; ethyl acetate / 24 h / 50 °C 3.1: aq. NaOH / 2 h / 20 °C 3.2: aq. H2SO4 / 3 h / 0 °C 3.3: 57 percent / aq. NaOH / 1 h / 20 °C / pH 7 4.1: 4-methylmorpholine; 2-chloro-4,6-dimethoxy-1,3,5-triazine / dimethylformamide / 2 h / 20 °C 4.2: 62 percent / 4-methylmorpholine / dimethylformamide / 3.5 h / 20 °C View Scheme

1.1: 90 percent / CH3SO2Cl; Et3N / CH2Cl2 / 0 - 20 °C 2.1: 91 percent / H2O; ethyl acetate / 24 h / 50 °C 3.1: aq. NaOH / 2 h / 20 °C 3.2: aq. H2SO4 / 3 h / 0 °C 3.3: 57 percent / aq. NaOH / 1 h / 20 °C / pH 7 View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / Pd(OAc)2<br />2: 72 percent / NaOH / ethanol<br /> <br /> &nbsp;