(2-羟基-5-甲基苯基)硼酸合成路线 (共 3 条)
参考文献
Eukarion, Inc.
Patent: US6177419 B1, 2001 ;
反应条件
1: 3-bromo-4-hydroxytoluene With n-butyllithium in diethyl ether; hexane
T=-90 - 20°C; 2 h; Inert atmosphere;
2: boric acid trimethyl ester in diethyl ether; hexane
T=-90 - 20°C; 15.5 h; Inert atmosphere;
3: With hydrogenchloride in diethyl ether; hexane; water
T=0°C; 0.5 h;
参考文献
Garcia-Lopez, Jose-Antonio; Greaney, Michael F.
Organic Letters, 2014 , vol. 16, # 9 p. 2338 - 2341
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C; Inert atmosphere;
2: With methanol in dichloromethane
T=-78°C; Inert atmosphere;
参考文献
Vishnumurthy, Kodumuru; Makriyannis, Alexandros
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 5 p. 664 - 669