(2-羟基-5-异丙基苯基)硼酸合成路线 （共 3 条）
参考文献
Eukarion, Inc.
Patent: US6177419 B1, 2001 ;
反应条件
1: With n-butyllithium in diethyl ether; hexane
T=20°C; 2.66667 h; Cooling with acetone-dry ice;
2: With boric acid trimethyl ester in diethyl ether; hexane
T=20°C; 18.5 h;
参考文献
Baguley, Tyler D.; Xu, Hai-Chao; Chatterjee, Manavi; Nairn, Angus C.; Lombroso, Paul J.; Ellman, Jonathan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7636 - 7650
反应条件
1.1: N-bromosuccinmide; diisopropylamine / dichloromethane / 1.5 h / 20 °C
2.1: n-butyllithium / hexane; diethyl ether / 2.67 h / 20 °C / |Cooling with acetone-dry ice
2.2: 18.5 h / 20 °C
View Scheme
参考文献
Baguley, Tyler D.; Xu, Hai-Chao; Chatterjee, Manavi; Nairn, Angus C.; Lombroso, Paul J.; Ellman, Jonathan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7636 - 7650
