N-[10-(13,14-亚甲二氧基苯基)-7(E),9(Z)-戊二烯酰基]-吡咯烷合成路线 （共 17 条）
反应条件
perchloric acid; sodium nitrite in water T=100°C; 2 h; other reaction conditions; Product distribution;
参考文献
Nakamura, Masamichi; Katoh, Kuni; Kawabata, Toshiharu
Agricultural and Biological Chemistry, 1981 , vol. 45, # 5 p. 1257 - 1260
反应条件
aluminum oxide; potassium hydroxide; dibromo-difluoro-methane in dichloromethane
T=20°C; 1 h;
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide
Amidation;
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
1: Et3N / CH2Cl2 / 0.5 h / 0 °C
2: 186 mg / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1: 60 percent / KOH / methanol / 2 h / Heating
2: Et3N / CH2Cl2 / 0.5 h / 0 °C
3: 186 mg / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
2.1: KOH / methanol / 0.17 h / 0 °C
2.2: 68 percent / methanol / 1 h / 0 °C
3.1: 90 percent / oxone / methanol; H2O / 0 °C
4.1: 85 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: methanol / 15 h / 20 °C
2: 80 percent / tetrahydrofuran / 2 h / 20 °C
3: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
4: 69 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
1: 80 percent / tetrahydrofuran / 2 h / 20 °C
2: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
3: 69 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
1: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
2: 69 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
2: 30 percent / mesyl chloride / pyridine / Ambient temperature
View Scheme
参考文献
Baldoli, Clara; Hellier, Paul; Licandro, Emanuela; Maiorana, Stefano; Manzotti, Raffaella; Papagni, Antonio
Tetrahedron Letters, 1997 , vol. 38, # 21 p. 3769 - 3772
