N-[10-(13,14-亚甲二氧基苯基)-7(E),9(Z)-戊二烯酰基]-吡咯烷合成路线 （共 17 条）
反应条件
in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1.1: KOH / methanol / 0.17 h / 0 °C
1.2: 68 percent / methanol / 1 h / 0 °C
2.1: 90 percent / oxone / methanol; H2O / 0 °C
3.1: 85 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
2.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
3.1: KOH / methanol / 0.17 h / 0 °C
3.2: 68 percent / methanol / 1 h / 0 °C
4.1: 90 percent / oxone / methanol; H2O / 0 °C
5.1: 85 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
in dichloromethane
amidation; 0.5 h;
参考文献
Koul, Surrinder; Koul, Jawahir L.; Taneja, Subhash C.; Dhar, Kanaya L.; Jamwal, Deshvir S.; Singh, Kuldeep; Reen, Rashmeet K.; Singh, Jaswant
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 251 - 268
反应条件
KN(SiMe3)2
1.) THF, hexane, RT, 1 h, 2.) THF, hexane, reflux; Yield given. Multistep reaction;
参考文献
Ohta, Akihiro; Tonomura, Yoshiko; Sawaki, Junko; Naohito, Sato; Akiike, Hitomi; et al.
Heterocycles, 1991 , vol. 32, # 5 p. 965 - 973
参考文献
Szeki
Mat. termeszettud. Ertesitoe, 1936 , vol. 54, p. 807,814
Chem. Zentralbl., 1937 , vol. 108, # I p. 1960
反应条件
1.) BF3OEt2 in refluxing toluene; 2.) oxidation (m-chloroperbenzoic acid, CH2Cl2,-78 grad C); 3.) reflux in toluene; Yield given. Multistep reaction;
参考文献
Nakai, Takeshi; Setoi, Hiroyuki; Kageyama, Yasuhide
Tetrahedron Letters, 1981 , vol. 22, # 41 p. 4097 - 4100
