2-甲基-4-硝基异吲哚-1,3-二酮合成路线 （共 9 条）
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 4 h; Inert atmosphereReflux; chemoselective reaction;
参考文献
Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R.
Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382
反应条件
nitric acid; anhydrous sulphate; zirconium oxide in tetrachloromethane T=20°C; 17 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Nagi, Sh. M.; Zubkov, E. A.; Shubin, V. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 7.2 p. 1500 - 1502
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 7 p. 1650 - 1652
参考文献
Sah; Ma
Chemische Berichte, 1932 , vol. 65, p. 1630,1631
参考文献
Dabard; Tirouflet
Bulletin de la Societe Chimique de France, 1957 , p. 565,569
反应条件
ammonium hydroxide; hydrogen; acetic acid; palladium monocarbide
参考文献
BIGGE, CHRISTOPHER F.; MALONE, THOMAS C.; WATJEN, FRANK
Patent: US2003/114422 A1, 2003 ;
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Dabard; Tirouflet
Bulletin de la Societe Chimique de France, 1957 , p. 565,569
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) r.t., 30 min., 2.) reflux, 90 min.;
参考文献
Knefeli, Frank; Mayer, Klaus K.; Wiegrebe, Wolfgang
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 419 - 426
反应条件
1: SnCl2; concentrated aqueous HCl
2: sodium nitrite; hydrochloric acid; water / Diazotization.beim Behandeln der erhaltenen Diazoniumsalz-Loesung mit Kupfer(I)-chlorid
View Scheme
参考文献
Dabard; Tirouflet
Bulletin de la Societe Chimique de France, 1957 , p. 565,569
反应条件
1: 1.57 g / N,N-dimethyl-acetamide / 0.5 h / 120 °C
2: polyphosphoric acid (PPA) / 1.5 h / 150 °C
View Scheme
参考文献
Fischer, Walter
Helvetica Chimica Acta, 1991 , vol. 74, # 5 p. 1119 - 1126
