1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐合成路线 （共 12 条）
反应条件
benzotriazol-1-ol in tetrahydrofuran; water; N,N-dimethyl-formamide
参考文献
Tobe, Takahiko; Sugane, Takashi; Hamaguchi, Wataru; Shimada, Itsuro; Maeno, Kyoichi; Miyata, Junji; Kimizuka, Tetsuya; Suzuki, Takeshi; Kohara, Atsuyuki; Morita, Takuma; Arlt, Michael; Greiner, Hartmut
Patent: US2003/216385 A1, 2003 ;
US 20030216385 A1
反应条件
triethylamine in dichloromethane T=0 - 25°C; 20 h; Product distribution / selectivity;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/275240 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 30 h; 2: With ammonia; water in dichloromethane
参考文献
LEK Pharmaceuticals d.d.
Patent: EP1953157 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: N-hydroxy-2-(4-nitrophenyl)acetimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: p-toluamidoxime With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: N'-hydroxy-4-methoxybenzimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: benzamidoxime With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: 2-(4-chlorophenyl)-N'-hydroxyacetimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20°C; Product distribution / selectivity;
参考文献
ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/49884 A1, 2009 ;
Location in patent: Page/Page column 21 ;
反应条件
sodium hydrogencarbonate; benzotriazol-1-ol
参考文献
Kowa Company, Ltd.
Patent: US6204278 B1, 2001 ;
