5-碘-5-脱氧胸腺嘧啶脱氧核苷合成路线 （共 9 条）
反应条件
1H-imidazole; iodine; triphenylphosphine in tetrahydrofuran T=20°C; 18 h; Inert atmosphere;
参考文献
Vernekar, Sanjeev Kumar V.; Qiu, Li; Zacharias, Jeana; Geraghty, Robert J.; Wang, Zhengqiang
MedChemComm, 2014 , vol. 5, # 5 p. 603 - 608
反应条件
pyridine; iodine; triphenylphosphine in 1,4-dioxane; methanol; water; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US5449664 A1, 1995 ;
反应条件
1: pyridine / Behandeln des Reaktionsprodukts mit wss.-methanol.NH3 2: NaI View Scheme
参考文献
Michelson; Todd
Journal of the Chemical Society, 1955 , p. 816,822
反应条件
1: Et4NF / acetonitrile / Heating 3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, -78 deg C, 4 min, 2.) CH2Cl2, -78 deg C, 15 min, then room t. 4: Et3N, MeOH / 0.08 h / Ambient temperature View Scheme
参考文献
Joshi, Bhalchandra V.; Reese, Colin B.
Tetrahedron Letters, 1993 , vol. 34, # 36 p. 5807 - 5810
反应条件
recombinant Escherichia coli thymidine phosphorylase T=37°C; pH=6.5; aq. buffer; Kinetics;
参考文献
Panova, Natalya G.; Alexeev, Cyril S.; Polyakov, Konstantin M.; Gavryushov, Sergei A.; Kritzyn, Anatoliy M.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1211 - 1214
参考文献
Michelson; Todd
Journal of the Chemical Society, 1955 , p. 816,822
反应条件
silver(I) acetate; acetonitrile
参考文献
Michelson; Todd
Journal of the Chemical Society, 1955 , p. 816,822
反应条件
1: propan-1-ol / 48 h / Heating
2: NaHSO3 / H2O / 0.17 h / 40 °C
View Scheme
参考文献
Dereu; Zingaro
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 8 p. 685 - 694
反应条件
1: propan-1-ol / 48 h / Heating
2: NaHSO3 / H2O / 0.17 h / 40 °C
3: diethylamine / CH2Cl2 / 0.25 h / Ambient temperature
View Scheme
参考文献
Dereu; Zingaro
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 8 p. 685 - 694
