1: With potassium carbonate in methanol; water T=20°C; 4 h; 2: With ammonium chloride in methanol; water

lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2.5 h;

(i) isopropenyl acetate, TsOH, NaOAc, (ii) NaBH4, aq. NaOH, EtOH; Multistep reaction;

sodium hydroxide; sodium tetrahydroborate in ethanol 1.) 5 deg C, 2.5 h, 2.) heating to boiling;

tetrahydrofuran; sodium tetrahydroborate; ethanol anschliessend Erwaermen mit wss. NaOH;

1: 79.2 percent / acetic anhydride / Heating 2: 61.2 percent / 1.) NaBH4, 2.) 5percent NaOH / aq. ethanol / 1.) 5 deg C, 2.5 h, 2.) heating to boiling View Scheme

暂无反应条件数据

暂无反应条件数据

1.1: 91 percent / pyridine; DMAP / CH2Cl2 / 3 h / 20 °C 2.1: 57 percent / Br2; AcOH; KOAc / diethyl ether / 14 h / 0 - 20 °C 3.1: 59 percent / K2CO3 / methanol; CH2Cl2; H2O / 5 h / 80 °C 4.1: 95 percent / PCC / CH2Cl2 / 3 h / 20 °C 5.1: LDA / tetrahydrofuran / 0.17 h / 0 °C 5.2: CDCl3 / 12 h / 20 °C View Scheme

1.1: 91 percent / pyridine; DMAP / CH2Cl2 / 3 h / 20 °C 2.1: BH3 / tetrahydrofuran / 2 h / 20 °C 2.2: 62 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran / 1.5 h / 0 - 20 °C 3.1: 97 percent / PCC / CH2Cl2 / 3 h / 20 °C 4.1: 99 percent / HC(OEt)3; p-TSA / CH2Cl2 / 3.5 h / 20 °C 5.1: 51 percent / NaHCO3 / methanol; H2O / 72 h / 67 °C 6.1: 96 percent / PCC / CH2Cl2 / 3 h / 20 °C 7.1: PhSeCl / ethyl acetate / 3 h / 20 °C 7.2: 70 percent / aq. H2O2 / ethyl acetate / 0.5 h 8.1: 195 mg / pyridine; DMAP / CH2Cl2 / 3 h / 20 °C 9.1: 64 percent / aq. HCl / acetone / 0.5 h / 20 °C 10.1: 72 percent / K-Selectride / tetrahydrofuran / 5.5 h / -78 °C 11.1: POCl3; pyridine / 1 h / 20 °C 12.1: 250 mg / K2CO3 / methanol; H2O / 1 h / Heating 13.1: 37 percent / MnO2 / acetone / 12 h / 20 °C View Scheme