4-氰基-3-甲基苯甲酸甲酯合成路线 （共 8 条）
反应条件
sodium carbonate; palladium diacetate in isobutyramide T=120°C; 15 h;
参考文献
PFIZER LIMITED; GIBSON, Karl Richard; GREEN, Martin Peter; UNDERWOOD, Toby James; WAKENHUT, Florian
Patent: WO2010/32200 A1, 2010 ;
Location in patent: Page/Page column 133 ;
WO 2010/032200 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 4 h;
参考文献
Pfizer Inc
Patent: US2007/270438 A1, 2007 ;
Location in patent: Page/Page column 42 ;
US 20070270438 A1
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
WO2006/21213 A2, ;
Page/Page column 27-28 ;
WO 2006/021213 A2
反应条件
in N-methyl-acetamide
反应条件
copper diacetate; triphenyl-phosphine oxide; silver(l) oxide T=125°C; 72 h;
参考文献
Song, Ren-Jie; Wu, Ji-Cheng; Liu, Yu; Deng, Guo-Bo; Wu, Cui-Yan; Wei, Wen-Ting; Li, Jin-Heng
Synlett, 2012 , vol. 23, # 17 p. 2491 - 2496,6
反应条件
hydrogenchloride; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4416 - 4420
反应条件
in N,N-dimethyl-formamide Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 24 p. 6707 - 6713
参考文献
Helvetica Chimica Acta, , vol. 20, p. 563,564
