3-氰-4-甲氧基苯甲酸甲酯合成路线 （共 8 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 2 h; Inert atmosphere;
参考文献
WO2009/158393 A1, ;
Page/Page column 109 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
US2012/184587 A1, ;
Page/Page column 33 ;
反应条件
NaH in ethyl acetate; N,N-dimethyl-formamide
参考文献
US5939439 A1, ;
US 5939439 A
反应条件
1: bromine / chloroform; methanol / 2 h 2: N,N-dimethyl-formamide / 16 h / 150 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
反应条件
1: N,N-dimethyl-formamide / 16 h / 150 °C 2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; tri-n-butyl phosphite; tri-iso-propylsilane in 2-cyclohexylethanol T=130°C; 15 h; Inert atmosphere;
参考文献
Tobisu, Mamoru; Nakamura, Ryo; Kita, Yusuke; Chatani, Naoto
Journal of the American Chemical Society, 2009 , vol. 131, p. 3174 - 3175
反应条件
pyridine hydrochloride T=180°C; 1 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: US2012/59012 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 1 h; 2: With hydrogenchloride in water pH=2; Product distribution / selectivity;
参考文献
ENVIVO PHARMACEUTICALS, INC.
Patent: WO2009/158393 A1, 2009 ;
Location in patent: Page/Page column 109-110 ;
