6-氟-3-羟基吡嗪-2-甲酰胺合成路线 （共 15 条）
反应条件
1: With water; sodium hydroxide in toluene T=20°C; 0.5 h; 2: With dihydrogen peroxide in toluene T=15 - 25°C; 0.5 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; FUJIFILM Corporation; NAKAMURA, Kouki; MURAKAMI, Takeshi; NAITOU, Hiroyuki; HANAKI, Naoyuki; WATANABE, Katsuyuki
Patent: US2013/245264 A1, 2013 ;
Location in patent: Paragraph 0213 ;
反应条件
1: With sulfuric acid T=50°C; 4 h; 2: With water T=3 - 10°C; 0.666667 h; 3: With sodium hydroxide in water T=10°C; 0.75 h;
参考文献
Nippon Soda Co., Ltd.
Patent: US2011/275817 A1, 2011 ;
Location in patent: Page/Page column 5-6 ;
反应条件
anhydrous sodium hydrogen carbonate; sodium chloride; ammonia in methanol; water; ethyl acetate
反应条件
anhydrous sodium hydrogen carbonate; sodium chloride; sulfuric acid; sodium nitrite in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; di-isopropyl ether; water; ethyl acetate
反应条件
1.1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 2.5 h / 60 °C 2.1: sodium acetate; water / toluene; dimethyl sulfoxide / 7 h / 50 °C 3.1: sulfuric acid / 4 h / 50 °C 3.2: 0.67 h / 3 - 10 °C 3.3: 0.75 h / 10 °C View Scheme
反应条件
1.1: sodium acetate; water / toluene; dimethyl sulfoxide / 7 h / 50 °C 2.1: sulfuric acid / 4 h / 50 °C 2.2: 0.67 h / 3 - 10 °C 2.3: 0.75 h / 10 °C View Scheme
反应条件
1.1: potassium fluoride / dimethyl sulfoxide / 4 h / 90 °C 2.1: sodium hydrogencarbonate; water / 4 h / 100 °C 2.2: 1.17 h / 20 °C 3.1: water; sodium hydroxide / toluene / 0.5 h / 20 °C 3.2: 0.5 h / 15 - 25 °C View Scheme
反应条件
1.1: sodium hydrogencarbonate; water / 4 h / 100 °C 1.2: 1.17 h / 20 °C 2.1: water; sodium hydroxide / toluene / 0.5 h / 20 °C 2.2: 0.5 h / 15 - 25 °C View Scheme
反应条件
1.1: potassium fluoride / dimethyl sulfoxide / 3 h / 80 °C / |Inert atmosphere 1.2: 3 h / 80 °C 1.3: 20 °C 2.1: water; sodium hydroxide / toluene / 0.5 h / 20 °C 2.2: 0.5 h / 15 - 25 °C View Scheme
