4,5,6,7-四氢-5-甲基-噻唑并[5,4-c]吡啶合成路线 （共 7 条）
反应条件
1: in DMF (N,N-dimethyl-formamide) T=80°C; 4 h; 2: With sodium tetrahydroborate in methanol T=20°C; 1 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: US2005/20645 A1, 2005 ;
反应条件
1: With sulfuric acid; hypophosphorous acid in water T=15 - 18°C; 2: With sodium nitrite in water T=-2 - 10°C; 3 h; 3: With potassium hydroxide in water pH=12.6;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1683800 A1, 2006 ;
Location in patent: Page/Page column 54 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2935 - 2939
反应条件
1: 51 percent / molecular sieves 4 Angstroem / ethanol 2: 40 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2935 - 2939
反应条件
1: dimethylformamide / 80 °C 2: NaBH4 / H2O View Scheme
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C 1.2: 46 percent / S8 / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 45 percent / formic acid / 2 h / Heating 3.1: dimethylformamide / 80 °C 4.1: NaBH4 / H2O View Scheme
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
反应条件
1: 45 percent / formic acid / 2 h / Heating 2: dimethylformamide / 80 °C 3: NaBH4 / H2O View Scheme
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
