7,8-二氢-2-(甲磺酰基)吡啶并[4,3-d]嘧啶-6(5H)-甲酸叔丁酯合成路线 （共 4 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 20°C; 4 h;
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
Location in patent: Page/Page column 136 ;
反应条件
1: 6 h / Reflux 2: sodium hydroxide / water / 1 h / 80 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme
反应条件
1: sodium hydroxide / water / 1 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme
反应条件
1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / Microwave irradiation
2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
2.2: Amberlyst A-21
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
