6,7-二氢-4H-吡喃并[4,3-d]噻唑-2-胺合成路线 （共 6 条）
反应条件
1: tetrahydro-pyran-4-one With pyrrolidine; toluene-4-sulfonic acid in cyclohexane 1.16667 h; Heating / reflux; 2: With sulfur in methanol T=20°C; 0.25 h; 3: Carbamonitrile in methanol 72 h;
参考文献
EP1577301 A1, ;
Page/Page column 81 ;
反应条件
1: tetrahydro-pyran-4-one With bromine in diethyl ether T=0°C; 0.833333 h; 2: thiourea in ethanol 1 h; Heating / reflux;
参考文献
WO2005/66145 A1, ;
Page/Page column 190-191 ;
WO 2005/066145 A1
反应条件
1: tetrahydro-pyran-4-one With pyrrolidine; toluene-4-sulfonic acid in cyclohexane 3 h; Heating / reflux; 2: Carbamonitrile With sulfur in methanol T=0 - 20°C;
参考文献
WO2009/67613 A1, ;
Page/Page column 129 ;
WO 2009/067613 A1
反应条件
1: pyrrolidine; tetrahydro-pyran-4-one With toluene-4-sulfonic acid in cyclohexane 1.16667 h; Heating / reflux; 2: Carbamonitrile With sulfur in methanol T=0°C; 72.5833 h;
参考文献
EP1577302 A1, ;
Page/Page column 78 ;
反应条件
Carbamonitrile; sulfur in methanol 72 h;
参考文献
EP1405852 A1, ;
Page 74 ;
EP 1405852 A1
反应条件
in tetrahydrofuran; ethanol 12 h; Reflux;
参考文献
WO2013/10453 A1, ;
Page/Page column 216 ;
