2-氟-4-甲基-5-硝基苯胺合成路线 （共 5 条）
反应条件
1.1: NaNO2; aq. HCl / 0.33 h / 0 °C 1.2: 75 percent / aq. HCl; CuCl / 16 h / 0 - 20 °C 2.1: dimethylformamide / 2 h / 130 °C 3.1: 124 g / hydrazine hydrate; Raney nickel / tetrahydrofuran; methanol; dimethylformamide / 16 h / 20 °C View Scheme
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0 - 5°C; 0.25 h; 2: With copper(I) oxide; hydrogen bromide in water T=0°C;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2008/77138 A1, 2008 ;
Location in patent: Page/Page column 76 ;
WO 2008/077138 A1
反应条件
sodium nitrite in water; hydrogen bromide
参考文献
Vernalis Research Limited
Patent: US6380238 B1, 2002 ;
反应条件
1.1: NaNO2; aq. HCl / 0.33 h / 0 °C
1.2: 75 percent / aq. HCl; CuCl / 16 h / 0 - 20 °C
2.1: 140 °C
View Scheme
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
反应条件
1.1: NaNO2; aq. HCl / 0.33 h / 0 °C
1.2: 75 percent / aq. HCl; CuCl / 16 h / 0 - 20 °C
2.1: 140 °C
2.2: hydrazine hydrate; Raney nickel / methanol / 20 °C
View Scheme
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
