copper(I) thiophene-2-carboxylate; diphenyl-N,N-bis-((S,S)-1-phenyl-ethyl)phosphinamine in diethyl ether; dichloromethane T=-20°C; 20.05 h; Inert atmosphere;

1: conc. HCl / methanol / 3 h / Heating 2: 72 percent / Et3N, DMAP / CH2Cl2 / 48 h / Ambient temperature 3: 70 percent / BF3*Et2O / 0.08 h / 140 °C 4: 46 percent / aq. ceric ammonium nitrate / acetonitrile / 0.05 h / 0 °C View Scheme

[Ru(CO)3Cl2]2 in 1,2-dichloro-ethane T=60°C; 18 h; Inert atmosphere; regioselective reaction;