2-[[(Z)-十八碳-9-烯酰基]氨基]乙酸合成路线 （共 3 条）
反应条件
1: (Z)-9-octadecenoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine in ethyl acetate T=20°C; 1 h; 2: glycine in ethyl acetate T=20°C; 12 h;
参考文献
Dang, Hung The; Kang, Gyeoung Jin; Yoo, Eun Sook; Hong, Jongki; Choi, Jae Sue; Kim, Hyung Sik; Chung, Hae Young; Jung, Jee H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1520 - 1527
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=0 - 20°C; 12 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; pH=2; Inert atmosphere;
参考文献
Osornio, Yazmin M.; Uebelhart, Peter; Bosshard, Silvan; Konrad, Fabian; Siegel, Jay S.; Landau, Ehud M.
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10583 - 10595
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C 2: sodium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C View Scheme
参考文献
Duarte, Rodrigo Da Costa; Ongaratto, Renata; Piovesan, Luciana Almeida; De Lima, Vania Rodrigues; Soldi, Valdir; Merlo, Aloir Antonio; D'Oca, Marcelo G. Montes
Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2454 - 2460
