3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2A]嘧啶-4酮 (帕潘立酮)合成路线 （共 6 条）
反应条件
trichlorophosphate in water; toluene
参考文献
ACTAVIS GROUP PTC EHF
Patent: US2010/4447 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogenchloride; hydrogen; 1 Pd/C in methanol; water T=25 - 30°C; P=735.572 - 1471.14 Torr; 1 h; Autoclave; Product distribution / selectivity;
参考文献
GLENMARK GENERICS LIMITED
Patent: WO2009/130710 A2, 2009 ;
Location in patent: Page/Page column 17-18 ;
反应条件
ammonium hydroxide; trichlorophosphate in water; toluene
参考文献
WATSON LABORATORIES, INC.; CHAVAN, Amit, Anant; BHANU, Manjunath, Narayan; JOSHI, Ashutosh, Vijay
Patent: WO2012/134445 A1, 2012 ;
Location in patent: Page/Page column 26; 27 ;
反应条件
1: toluene-4-sulfonic acid / xylene / 20.5 h / 25 - 142 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 21 h / 38 - 43 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai
Patent: WO2011/73997 A2, 2011 ;
反应条件
1: toluene-4-sulfonic acid / xylene / 20.5 h / 25 - 142 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 21 h / 38 - 43 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai
Patent: WO2011/73997 A2, 2011 ;
反应条件
1: With ethylenediaminetetraacetic acid in water 2: With sodium carbonate in water
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai
Patent: WO2011/73997 A2, 2011 ;
Location in patent: Page/Page column 14 ;
