alpha-(2-氯乙基)-2-噻吩甲醇合成路线 (共 4 条)
反应条件
1: With sodium tetrahydroborate in dichloromethane; sodium lauryl sulfate T=20 - 35°C; 3 h; 2: With acetic acid in dichloromethane; sodium lauryl sulfate
参考文献
WO2008/81476 A2, ;
Page/Page column 36; 39 ;
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol; water; toluene T=0°C; 3.16667 h;
参考文献
WO2005/73215 A1, ;
Page/Page column 3-4 ;
反应条件
Novozyme in hexane T=30°C; 22 h; Enzymatic reaction;
参考文献
Cashman, John R.; Ghirmai, Senait
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 19 p. 6890 - 6897
反应条件
succinic acid anhydride; lipase in tert-butyl methyl ether T=20°C; 20 h;
参考文献
BASF Aktiengesellschaft
Patent: WO2005/73215 A1, 2005 ;
Location in patent: Page/Page column 4 ;