3-(甲基硒基)-L-丙氨酸合成路线 （共 7 条）
反应条件
1: dimethyl diselenide With sodium hydroxide; sodium tetrahydroborate in DMF (N,N-dimethyl-formamide); water T=5 - 45°C; 2 h; 2: β-chloro-L-alanine hydrochloride in DMF (N,N-dimethyl-formamide); water T=5 - 45°C; 2.5 h;
参考文献
Sami Labs Limited
Patent: US6794537 B1, 2004 ;
Location in patent: Page column 5-6 ;
反应条件
1: dimethyl diselenide With sodium hydroxide; sodium tetrahydroborate in DMF (N,N-dimethyl-formamide); water T=5 - 45°C; 3 h; 2: β-chloroalanine methyl ester in DMF (N,N-dimethyl-formamide); water T=0 - 20°C; 6.5 h;
参考文献
Sami Labs Limited
Patent: US6794537 B1, 2004 ;
Location in patent: Page column 5 ;
反应条件
ammonia; sodium 1.) -70 deg C; Yield given. Multistep reaction;
参考文献
Andreadou; Menge; Commandeur; Worthington; Vermeulen
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2040 - 2046
参考文献
PharmaSe, Incorporated
Patent: EP1205471 A1, 2002 ;
Location in patent: Page 6 ;
反应条件
phosphate buffer; Crotalus adamanteus L-amino acid oxidase; N-(carboxymethoxy)-amine T=37°C; pH=7.2; 0.333333 h; Enzyme kineticsProduct distribution; Further Variations:Reagents;
参考文献
Rooseboom; Vermeulen; Van Hemert; Commandeur
Chemical Research in Toxicology, 2001 , vol. 14, # 8 p. 996 - 1005
反应条件
acetic acid; benzaldehyde T=20 - 60°C; 2.58333 h;
参考文献
Sami Labs Limited
Patent: US6794537 B1, 2004 ;
Location in patent: Page column 6 ;
反应条件
acetic acid; benzaldehyde T=20 - 60°C; 2.58333 h;
参考文献
Sami Labs Limited
Patent: US6794537 B1, 2004 ;
Location in patent: Page column 6 ;
