N-苯氧基碳-L-苯丙氨酰甲基氯酮合成路线 （共 25 条）
反应条件
hydrogen bromide in acetic acid
参考文献
Fittkau, Siegfried; Jahreis, Guenther; Peters, Klaus; Balaspiri, Lajos
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 529 - 538
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol T=-2 - 20°C; 1.66667 - 3.66667 h; 2: With potassium hydrogensulfate in water; ethyl acetate 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
US6388132 B1, ;
Page column 44-45,51 ;
反应条件
aluminum isopropoxide; isopropyl alcohol in toluene T=50°C; Meerwein-Ponndorf-Verley reduction; 18 h;
参考文献
Journal of Organic Chemistry, , vol. 71, # 2 p. 840 - 843
反应条件
1: 94 percent / aluminum isopropoxide; isopropyl alcohol / toluene / 18 h / 50 °C 2: 99 percent / potassium hydroxide / ethanol / 1 h / 20 °C View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
sodium hydrogencarbonate in water; toluene
参考文献
AJINOMOTO CO., INC.
Patent: US2002/35288 A1, 2002 ;
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Fittkau, Siegfried; Jahreis, Guenther; Peters, Klaus; Balaspiri, Lajos
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 529 - 538
反应条件
formic acid
T=80°C; 0.333333 h;
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Izawa, Kunisuke
Organic Letters, 2002 , vol. 4, # 3 p. 447 - 449
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-75°C; 0.166667 h;
参考文献
Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3175 - 3178
反应条件
sodium hydrogencarbonate in water; toluene
T=20°C; Schotten Baumann acylation; 1 h;
参考文献
Onishi, Tomoyuki; Nakano, Takashi; Hirose, Naoko; Nakazawa, Masakazu; Izawa, Kunisuke
Tetrahedron Letters, 2001 , vol. 42, # 34 p. 5887 - 5890
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
参考文献
Onishi, Tomoyuki; Hirose, Naoko; Nakano, Takashi; Nakazawa, Masakazu; Izawa, Kunisuke
Tetrahedron Letters, 2001 , vol. 42, # 34 p. 5883 - 5885
