N-苯氧基碳-L-苯丙氨酰甲基氯酮合成路线 （共 25 条）
反应条件
1: 66 percent / aq. HCl / tetrahydrofuran / 11 h / 20 °C
2: 83 percent / NaHCO3 / toluene; H2O / 1 h / 20 °C
View Scheme
参考文献
Onishi, Tomoyuki; Nakano, Takashi; Hirose, Naoko; Nakazawa, Masakazu; Izawa, Kunisuke
Tetrahedron Letters, 2001 , vol. 42, # 34 p. 5887 - 5890
反应条件
1: potassium hydroxide / methanol; water / 1.17 h / 20 °C
2: hydrogenchloride / diethyl ether / 0.25 h / 0 °C
View Scheme
参考文献
Pinho, Vagner D.; Gutmann, Bernhard; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.; Kappe, C. Oliver
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1555 - 1562
反应条件
hydrogenchloride
1.) THF, 4 deg C, 15 h; 2.) THF, dioxane, -15 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4794 - 4801
反应条件
Yield given. Multistep reaction;
参考文献
Ng, John S.; Przybyla, Claire A.; Liu, Chin; Yen, Joe C.; Muellner, Frank W.; Weyker, Cara L.
Tetrahedron, 1995 , vol. 51, # 23 p. 6397 - 6410
反应条件
1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C
2: H2 / Pd/C / methanol / 4.5 h / 5 °C
3: aq. Na2CO3 / CH2Cl2 / 1 h / 20 °C
4: K2CO3 / methanol / 6 h / 20 °C
5: 7.55 g / ethanol / 3 h / Heating
6: aq. K2CO3 / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070
