2-氯-6-甲氧基苯并噻唑合成路线 （共 14 条）
反应条件
polyethylene glycol; copper dichloride; isopentyl nitrite in acetonitrile T=65°C; 3 h;
参考文献
Suzuki, Nobutaka; Nomoto, Tateo; Toya, Yoshiaki; Kanamori, Norio; Yoda, Binkoh; Saeki, Akio
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 9 p. 1561 - 1562
反应条件
sodium nitrite; Copper(I)chloride in hydrogenchloride; methanol; formic acid; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; acetic acid; ethyl acetate
参考文献
Boehringer Mannheim GmbH
Patent: US4826989 A1, 1989 ;
反应条件
thionyl chloride T=50°C; 2 h;
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
1: bromine; acetic acid / 0.5 h / 0 °C 2: hydrazine monohydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C 3: thionyl chloride / 2 h / 50 °C View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
(i) KSCN, Br2, (ii) aq. NaOH, (iii) /BRN= 1098293/, (iv) SO2Cl2; Multistep reaction;
参考文献
Bouanane,A. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1976 , vol. 283, p. 319 - 321
反应条件
trimethylsilyl iodide in diethyl ether; chloroform; dimethyl sulfoxide
参考文献
Boehringer Mannheim GmbH
Patent: US4826989 A1, 1989 ;
反应条件
1: chlorobenzene; AlCl3 2: NaOH; xylene View Scheme
参考文献
Utsumi et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 238,240
Chem.Abstr., 1955 , p. 3163
反应条件
1: With AlCl3, aluminium chloride in toluene T=110°C; 1 h; 2: With hydrogenchloride; water in toluene T=20°C;
参考文献
CRITICAL THERAPEUTICS, INC.
Patent: WO2007/146066 A2, 2007 ;
Location in patent: Page/Page column 91 ;
反应条件
sodium hydroxide; trimethylsilyl iodide in methanol; chloroform; water
参考文献
Boehringer Mannheim GmbH
Patent: US4826989 A1, 1989 ;
反应条件
hydrazine hydrate in ethanol; water 3 h; Reflux;
参考文献
Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet
Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265
