2-(2-噻吩)-4H-3,1-苯并噁嗪-4-酮合成路线 （共 9 条）
反应条件
acetic anhydride; triethylamine in ethyl acetate
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5939421 A1, 1999 ;
反应条件
potassium phosphate; copper(l) iodide; calcium chloride in toluene T=140°C; 48 h; Sealed tubeInert atmosphere;
参考文献
Ge, Zhi-Yuan; Xu, Qiong-Ming; Fei, Xi'Ang-Dong; Tang, Ting; Zhu, Yong-Ming; Ji, Shun-Jun
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4524 - 4529
反应条件
in various solvent(s) 18 h; Heating;
参考文献
Deck; Turner; Papadopoulos
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 2 p. 343 - 347
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: 57 percent / SnCl4 / 16 h / 20 °C 2: 93 percent / aq. NaOH / 0.5 h / Heating 3: 76 percent / various solvent(s) / 18 h / Heating View Scheme
参考文献
Deck; Turner; Papadopoulos
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 2 p. 343 - 347
反应条件
1: 93 percent / aq. NaOH / 0.5 h / Heating 2: 76 percent / various solvent(s) / 18 h / Heating View Scheme
参考文献
Deck; Turner; Papadopoulos
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 2 p. 343 - 347
反应条件
acetic anhydride 1 h; Heating;
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: AcONH4 / 7 h / 220 °C
2: POCl3 / 3 h / Heating
View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
