二乙基(4-硝基苯甲基)磷酸盐合成路线 （共 31 条）
参考文献
Barton, John W.; Buhaenko, Michael; Moyle, Brian; Ratcliffe, Norman M.
Journal of the Chemical Society, Chemical Communications, 1988 , # 7 p. 488 - 489
反应条件
1: sodium tetrahydroborate / methanol / 0 °C 2: phosphorus tribromide; pyridine / 0 °C 3: 120 °C View Scheme
参考文献
Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu
Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859
反应条件
1: phosphorus tribromide; pyridine / 0 °C 2: 120 °C View Scheme
参考文献
Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu
Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859
参考文献
Fang, Zhengjun; Cao, Chenzhong; Chen, Guanfan
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1343 - 1350
反应条件
sodium hydride 1.) dimethoxyethane, 2.) dimethoxyethane, overnight; Yield given. Multistep reaction;
参考文献
Mangold; Hanna
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 630 - 638
反应条件
1: NSC 82303 With sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1.5 h; 2: 4-fluorobenzaldehyde in DMF (N,N-dimethyl-formamide) T=-10 - 20°C; 0.75 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2003/99763 A1, 2003 ;
Location in patent: Page 34 ;
反应条件
water; iron; ammonium chloride in ethanol 1 h; Reflux;
参考文献
ARDELYX, INC.; CHARMOT, Dominique; JACOBS, Jeffrey, W.; LEADBETTER, Michael, Robert; NAVRE, Marc; CARRERAS, Chris; BELL, Noah
Patent: WO2010/78449 A2, 2010 ;
Location in patent: Page/Page column 152 ;
WO 2010/078449 A2
反应条件
1: NaH / dimethylformamide 2: SnCl2 / H2O; ethanol View Scheme
参考文献
Fang, Zhengjun; Cao, Chenzhong; Chen, Guanfan
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1343 - 1350
反应条件
sodium ethanolate in ethanol T=20°C;
参考文献
Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 261 - 274
反应条件
sodium methylate in methanol T=20°C; 16 h; Cooling with ice;
参考文献
Astellas Pharma Inc.; HACHIYA, Shunichiro; MIURA, Masanori; IMAMURA, Yoshimasa; KAGA, Daisuke; SATO, Ippei; MORITOMO, Hiroyuki; KATO, Koji; TERAI, Kazuhiro; TERADA, Yoh
Patent: EP2565190 A1, 2013 ;
Location in patent: Paragraph 0102 ;
