二乙基(4-硝基苯甲基)磷酸盐合成路线 （共 31 条）
反应条件
hydrogenchloride in water 18 h; Reflux;
参考文献
Al-Riyami, Lamyaa; Pineda, Miguel A.; Rzepecka, Justyna; Huggan, Judith K.; Khalaf, Abedawn I.; Suckling, Colin J.; Scott, Fraser J.; Rodgers, David T.; Harnett, Margaret M.; Harnett, William
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9982 - 10002
反应条件
1: 80 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature
2: 8 percent / t-BuOK, air / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Akiyama, Shuzo; Tajima, Kunihiko; Nakatsuji, Shin'ichi; Nakashima, Kenichiro; Abiru, Kazuko; Watanabe, Miwa
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2043 - 2052
反应条件
1: NaH / tetrahydrofuran / 16 h / 70 °C
2: NaOH / methanol / 12 h / 80 °C
View Scheme
参考文献
Lee Yeong-Beom; Woo, Han Young; Yoon, Chong-Bok; Shim, Hong-Ku
Journal of Materials Chemistry, 1999 , vol. 9, # 10 p. 2345 - 2350
反应条件
1: 88 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature
2: 8 percent / t-BuOK, air / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Akiyama, Shuzo; Tajima, Kunihiko; Nakatsuji, Shin'ichi; Nakashima, Kenichiro; Abiru, Kazuko; Watanabe, Miwa
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2043 - 2052
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
Bergmann,E.D.; Solomonovici,A.
Synthesis, 1970 , p. 183 - 189
反应条件
1: 88 percent / sodium ethoxide / ethanol / 0.5 h / Ambient temperature
2: 57 percent / SnCl2, concd. HCl / acetic acid / Ambient temperature
View Scheme
参考文献
Fang, Zhengjun; Cao, Chenzhong; Chen, Guanfan
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1343 - 1350
反应条件
sodium ethanolate in ethanol; N,N-dimethyl-formamide
3 h; Ambient temperature;
参考文献
Akiyama, Shuzo; Tajima, Kunihiko; Nakatsuji, Shin'ichi; Nakashima, Kenichiro; Abiru, Kazuko; Watanabe, Miwa
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2043 - 2052
反应条件
(aminomethyl)polystyrene; carbon tetrabromide; Di-tert-butylcarbodiimide; sodium methylate; potassium hexamethylsilazane; benzotriazol-1-ol; 4-hydroxymethyl-phenoxy acetic acid; triphenylphosphine; trifluoroacetic acid
1.) CH2Cl2, DMF, overnight, 2.) CH2Cl2, 0 deg C, 3.) DMF, overnight, 4.) DMF, overnight, 5.) H2O, 2 h; Yield given. Multistep reaction;
参考文献
Howard Adams; Cook, Ronald M.; Hudson, Derek; Jammalamadaka, Vasu; Lyttle, Matthew H.; Songster, Michael F.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3706 - 3716
反应条件
1.1: sodium methylate / N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere
1.2: 12 h / 20 °C / |Inert atmosphere
2.1: tin(ll) chloride / ethyl acetate / 4 h / 90 °C
View Scheme
参考文献
Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu
Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859
反应条件
sulfur; sodium hydride
1.) THF, 1 h, 2.) reflux, 7 h; Yield given. Multistep reaction;
参考文献
Okuma, Kentaro; Ikari, Koumei; Ohta, Hiroshi
Chemistry Letters, 1992 , # 1 p. 131 - 134
