10H-吡啶并(3,2-b)(1,4)苯并噻嗪合成路线 （共 25 条）
反应条件
iodine; sulfur T=160 - 180°C;
参考文献
Atkinson; Russ; Tucker
Journal of medicinal chemistry, 1971 , vol. 14, # 10 p. 1005 - 1007
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in dimethyl sulfoxide T=170°C; 24 h; Inert atmosphere;
参考文献
Beresneva; Abele
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 9 p. 1420 - 1422
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 9 p. 1521 - 1524,3
反应条件
1: K3PO4; X-phos / Pd2dba3 / toluene / 20 h / Heating 2: sulfur; I2 / H2O / 0.33 h / 190 °C / microwave irradiation View Scheme
参考文献
Madrid, Peter B.; Polgar, Willma E.; Toll, Lawrence; Tanga, Mary J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3014 - 3017
反应条件
1: K3PO4; X-phos / Pd2dba3 / toluene / 20 h / Heating 2: sulfur; I2 / H2O / 0.33 h / 190 °C / microwave irradiation View Scheme
参考文献
Madrid, Peter B.; Polgar, Willma E.; Toll, Lawrence; Tanga, Mary J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3014 - 3017
反应条件
2: aq.-ethanolic KOH 3: aq.-ethanolic HCl View Scheme
参考文献
Kushwaha, Khushbu; Sakhuja, Rajeev; Jain, Subhash C.
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4459 - 4467
反应条件
1: aq.-ethanolic KOH 2: aq.-ethanolic HCl View Scheme
参考文献
Kushwaha, Khushbu; Sakhuja, Rajeev; Jain, Subhash C.
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4459 - 4467
参考文献
Yale; Sowinski
Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653
反应条件
1: methanol; ethanol; KOH-solution / anschliessenden Erwaermen mit 2-Chlor-3-nitro-pyridin 3: aq.-ethanolic KOH 4: aq.-ethanolic HCl View Scheme
参考文献
Yale; Sowinski
Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653
参考文献
Gennaro
Journal of Organic Chemistry, 1959 , vol. 24, p. 1156
反应条件
sodium amide; xylene
参考文献
Yale; Sowinski
Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653
