N-乙基-2-氨甲基吡咯烷合成路线 （共 34 条）
反应条件
chloroformic acid ethyl ester; triethylamine
1.)DMF, 0 deg C, 30 min, 2.) room temp. overnight; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
参考文献
Ciba-Geigy Corporation
Patent: US4089960 A1, 1978 ;
反应条件
1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature
2: 51 percent / Sn, HCl aq. / 4 h / 50 °C
3: 37 percent / pyridine / 0.5 h / Ambient temperature
View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shiomi, Teruo; Eigyo, Masami; Hirose, Katsumi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1137 - 1141
反应条件
1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature
2: 81 percent / Sn, HCl aq. / 4 h / 50 °C
3: Et3N / CH2Cl2 / 0.25 h
4: 29 percent / TFA / 3 h / Ambient temperature
View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shiomi, Teruo; Eigyo, Masami; Hirose, Katsumi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1137 - 1141
反应条件
thionyl chloride in diethyl ether; water; toluene
参考文献
Astra Lakemedel Aktiebolag
Patent: US4232037 A1, 1980 ;
US 4232037 A
反应条件
in butanone
2 h; Ambient temperature; Yield given;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
sodium hydroxide; thionyl chloride in water; toluene; butanone
参考文献
Astra Lakemedel Aktiebolag
Patent: US4232037 A1, 1980 ;
US 4232037 A
反应条件
in butanone
0.5 h; Yield given;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
in butanone
Ambient temperature; Yield given;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 33 percent / H2O / 12 h / Ambient temperature
2: 45 percent / 1.) liquid NH3, Na, Fe(NO3)3; 2.) NH4Cl / 1.) 1 h, dioxane; 2.) 1 h, reflux; 2 h, room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
