N-乙基-2-氨甲基吡咯烷合成路线 （共 34 条）
反应条件
chloroformic acid ethyl ester; triethylamine
1.)THF, 0 deg C, 30 min, 2.) room temp. overnight; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature
2: 81 percent / Sn, HCl aq. / 4 h / 50 °C
3: CH2Cl2 / 0.25 h / Ambient temperature
4: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min
5: 13 percent / Et3N / CH2Cl2 / 0.25 h
6: TFA / 1.) reflux, 2.) 50 deg C, 30 min
View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shiomi, Teruo; Eigyo, Masami; Hirose, Katsumi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1137 - 1141
反应条件
pyridine; sodium hydroxide; anhydrous phosphorus trichloride; sodium hydrogencarbonate in water
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4041032 A1, 1977 ;
反应条件
in hydrogenchloride; methanol; chloroform; toluene
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4041032 A1, 1977 ;
