1: 1-Diethoxymethylindole-5-carbonitrile With Merrifield resin bound glycerol; toluene-4-sulfonic acid in 1,4-dioxane T=20°C; Solid phase reaction; Transacetalization; 3 h; 2: N,N-dimethyl(methylene)ammonium chloride in N,N-dimethyl-formamide T=20°C; Solid phase reaction; Substitution; 48 h; 3: With hydrogenchloride; water in 1,4-dioxane T=40°C; Solid phase reaction; Hydrolysis; 3 h;

1: With Merrifield resin bound glycerol; toluene-4-sulfonic acid in 1,4-dioxane T=20°C; Solid phase reaction; Transacetalization; 3 h; 2: With hydrogenchloride; water in 1,4-dioxane T=40°C; Solid phase reaction; Hydrolysis; 3 h;

T=160&deg;C;&nbsp;Substitution;&nbsp;24&nbsp;h;&nbsp;<br /> &nbsp;