sodium hydroxide in ethanol; water T=50°C; 2 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=20&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 50 percent / LiCl; Na₂CO₃ / Pd(OAc)2 / dimethylformamide / 100 &deg;C<br />2: 82 percent / aq. HCl / tetrahydrofuran / 4 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 68 percent / sodium bicarbonate; iodine / H₂O / 5 h / 20 &deg;C<br />2: 50 percent / LiCl; Na₂CO₃ / Pd(OAc)2 / dimethylformamide / 100 &deg;C<br />3: 82 percent / aq. HCl / tetrahydrofuran / 4 h / 20 &deg;C<br /> <br /> &nbsp;