6-(4-氯苯基)-2-氧代-1,2-二氢-3-吡啶羧酸合成路线 （共 6 条）
反应条件
water; sodium hydroxide in 1,4-dioxane T=60°C; pH=10 - 14; 2 h;
参考文献
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences; Huang, Hanmin; Xia, Chungu; Xie, Pan
Patent: US2013/303798 A1, 2013 ;
Location in patent: Paragraph 0018; 0052; 0053 ;
反应条件
1: With morpholine; toluene-4-sulfonic acid; sulfur T=130°C; 5 h; 2: With potassium hydroxide in ethanol Reflux; 3: With hydrogenchloride in water pH=2;
参考文献
PROBIODRUG AG
Patent: US2011/92501 A1, 2011 ;
Location in patent: Page/Page column 112-113 ;
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=20°C; 5 h; 2: in tetrahydrofuran; water
参考文献
ASTRAZENECA AB
Patent: WO2008/112440 A1, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/112440 A1
反应条件
1: Pd(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)Cl2; di-tert-butyl peroxide / 16 h / 120 °C / 7600.51 Torr 2: water; sodium hydroxide / 1,4-dioxane / 2 h / 60 °C / pH 10 - 14 View Scheme
参考文献
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences; Huang, Hanmin; Xia, Chungu; Xie, Pan
Patent: US2013/303798 A1, 2013 ;
参考文献
Profft; Drux
Journal fuer Praktische Chemie (Leipzig), 1956 , vol. <4> 3, p. 274,275
反应条件
1: sodium ethylate; ethanol 2: aq. NaOH solution View Scheme
参考文献
Carter; Hey
Journal of the Chemical Society, 1948 , p. 147
