2-正丙基-1,3-丙二醇合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 48 h; Heating;
参考文献
Poldy, Jacqueline; Peakall, Rod; Barrow, Russell A.
Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2446 - 2449
反应条件
1: hexane / 16 h / 20 °C 2: tris(trimethylsilyl)silane; AIBN / benzene / 20 h / 80 °C 3: NaOH; hydrogen peroxide / H2O / 2 h / 20 °C View Scheme
参考文献
Batey, Robert A.; Smil, David V.
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9183 - 9187
反应条件
T=150°C; P=257428 Torr; Hydrogenation;
参考文献
Adkins; Billica
Journal of the American Chemical Society, 1948 , vol. 70, p. 3121
反应条件
T=50 - 60°C; Produkt 5: Propylmalonsaeure;
参考文献
Boeeseken; Takes
Recueil des Travaux Chimiques des Pays-Bas, 1937 , vol. 56, p. 859
反应条件
Irradiation.mit UV-Licht;
参考文献
Pummerer et al.
Chemische Berichte, 1942 , vol. 75, p. 880
反应条件
1: 71 percent / pyridine / 16 h / Ambient temperature
2: 55 percent / NaH / dioxane / 7 h / Heating
3: 1.) aq.KOH, aq.HCl / 1.) ethanol, reflux, 4 h; 2.) 180°C, 30 min
View Scheme
参考文献
Escale; Girard; Vergnon; et al.
European Journal of Medicinal Chemistry, 1977 , vol. 12, # 6 p. 501 - 509
反应条件
1.1: 65 percent / bromine; PPh3; pyridine / CH2Cl2 / 18 h / 20 °C
2.1: 86 percent / Bu3SnOMe / 50 °C / 75.01 Torr
3.1: lithium 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 0.67 h / -70 - -60 °C
3.2: 74 percent / BF3*OEt2 / tetrahydrofuran; hexane / 10 h / 20 °C
View Scheme
参考文献
Kirsch, Peer; Maillard, David
European Journal of Organic Chemistry, 2006 , # 15 p. 3326 - 3331
反应条件
pyridine; bromine; triphenylphosphine in dichloromethane
T=20°C; 18 h;
参考文献
Kirsch, Peer; Maillard, David
European Journal of Organic Chemistry, 2006 , # 15 p. 3326 - 3331
反应条件
(i) MeSO2Cl, Py, (ii) /BRN= 4652394/, (iii) aq. NaOH; Multistep reaction;
参考文献
Irwin,A.J. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1978 , p. 1636 - 1642
