2-苄基丙烷-1,3-二醇合成路线 （共 23 条）
反应条件
1: hexane / 16 h / 20 °C
2: tris(trimethylsilyl)silane; AIBN / benzene / 20 h / 80 °C
3: NaOH; hydrogen peroxide / H2O / 2 h / 20 °C
View Scheme
参考文献
Batey, Robert A.; Smil, David V.
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9183 - 9187
反应条件
dihydrogen peroxide; tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile
1.) benzene, reflux, 1-2 h; 2.) DMF,KF, 60 deg C, 7-8 h; Yield given. Multistep reaction;
参考文献
Nishiyama, Hisao; Kitajima, Toshio; Matsumoto, Makoto; Itoh, Kenji
Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2298 - 2300
反应条件
1: 77 percent / K2CO3 / acetone / Heating
2: 100 percent / LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Jenmalm, Annika; Berts, Wei; Li, Yi-Lin; Luthman, Kristina; Csoeregh, Ingeborg; Hacksell, Uli
Journal of Organic Chemistry, 1994 , vol. 59, # 5 p. 1139 - 1148
反应条件
1: NaH / dimethylformamide; tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) r.t., 12 h
2: LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Itoh; Chika; Takagi; Nishiyama
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5717 - 5723
反应条件
lithium aluminium tetrahydride
1) ethanol; 2) diethyl ether; Multistep reaction;
参考文献
Tombo, G. M. Ramos; Schaer, H.-P.; Busquets Fernandez I; Ghisalba, O.
Tetrahedron Letters, 1986 , vol. 27, # 47 p. 5707 - 5710
反应条件
1: lipase PS Amano / 48 h / 25 °C
2: Jones reagent / acetone / 0.17 h / 0 °C
3: LiOH / tetrahydrofuran; H2O / 1 h / 0 °C
View Scheme
参考文献
Atsuumi, Shugo; Nakano, Masato; Koike, Yutaka; Tanaka, Seiichi; Ohkubo, Mitsuru; Yonezawa, Toshiko; Funabashi, Hiroshi; Hashimoto, Junko; Morishima, Hajime
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1601 - 1604
反应条件
1: 83 percent / Et3N / CH2Cl2 / 2 h
2: 100 percent / Et3N / CH2Cl2 / 5 h / -30 °C
3: 83 percent / NaN3 / dimethylformamide / 24 h / 50 °C
4: LiAlH4 / diethyl ether / 3 h
5: 133 mg / NaF / H2O; diethyl ether
View Scheme
参考文献
Angle, Steven R.; Belanger, Dominique S.
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4361 - 4368
反应条件
1: Et3N / CH2Cl2 / 2.5 h / -30 °C
2: sodium azide / dimethylformamide / 50 °C
3: H2O; PPh3 / tetrahydrofuran / 0.33 h / 50 °C
View Scheme
参考文献
Banfi, Luca; Guanti, Giuseppe; Riva, Renata
Tetrahedron Asymmetry, 1999 , vol. 10, # 18 p. 3571 - 3592
反应条件
in chloroform
T=20°C; 0.5 h;
参考文献
Mirilashvili, Sima; Chasid-Rubinstein, Naama; Albeck, Amnon
European Journal of Organic Chemistry, 2008 , # 20 p. 3461 - 3464
反应条件
toluene-4-sulfonic acid in dichloromethane
T=20°C; 2 h;
参考文献
Lee, Jeewoo; Lee, Jiyoun; Kim, Jiyoung; Kim, Soo Yeon; Chun, Moon Woo; Cho, Hawon; Hwang, Sun Wook; Oh, Uhtaek; Park, Young Ho; Marquez, Victor E.; Beheshti, Maryam; Szabo, Tamas; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 19 - 32
