4-(4-溴苯基)-2-噻吩羧酸甲酯合成路线 （共 3 条）
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; 1 h; 2: With hydrogen bromide; copper(I) bromide in water T=0°C; 1 h;
参考文献
WARNER-LAMBERT COMPANY LLC.
Patent: WO2004/14381 A2, 2004 ;
Location in patent: Page/Page column 43 ;
反应条件
in N,N-dimethyl-formamide 18 h; Heating;
参考文献
Clemens, Ryan T.; Smith, Stanton Q.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1319 - 1320
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
T=80°C; Suzuki coupling;
参考文献
WARNER-LAMBERT COMPANY LLC.
Patent: WO2004/14381 A2, 2004 ;
Location in patent: Page/Page column 43-44 ;
