sulfuric acid T=23°C; 12 h;

in methanol; dichloromethane T=0°C;

4-methyl-morpholine; triethylamine; chlorodiphenylphosphine oxide 1.) CH2Cl2, -23 deg C, 28 min, 2.) CH2Cl2, 10 min, -23 deg C, 10 min, 0 deg C, 1.5 h, r.t.; Yield given. Multistep reaction;

暂无反应条件数据

1: 54 percent / Br2 / CCl4; CH2Cl2 / 0.08 h / Ambient temperature 2: 98 percent / K2CO3 / acetone / 1.5 h / Heating 3: 55 percent / dimethylformamide / 2 h / Heating 4: NaOH, water / methanol / 84 h / Heating View Scheme

1: 54 percent / Br2 / CCl4; CH2Cl2 / 0.08 h / Ambient temperature 2: 98 percent / K2CO3 / acetone / 1.5 h / Heating 3: 1.) Br2, 2.) silver trifluoroacetate in benzene / 1.) CCl4, a) irrad., reflux, 5.75 h, b) reflux, 1.5 h, 2.) CCl4, benzene, 2.5 h 4: lithium methoxide / dimethylformamide / 14 h / 90 °C 5: 92 percent / conc. HCl, H2 / 10 percent Pd/C / acetic acid 6: 98 percent / Br2 / CH2Cl2 7: 68 percent / copper bronze / 2 h / 210 °C 8: 96 percent / LiAlH4 / diethyl ether / 1 h / Heating 9: 88 percent / pyridinium chlorochromate / CH2Cl2 / 0.5 h / Ambient temperature 10: 96 percent / butyllithium / hexane; tetrahydrofuran / 0.5 h / Ambient temperature 11: 92 percent / hexamethylphosphoric acid triamide / 2 h / 160 °C View Scheme

caesium carbonate; 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=20°C;

1: 54 percent / Br2 / CCl4; CH2Cl2 / 0.08 h / Ambient temperature 2: 98 percent / K2CO3 / acetone / 1.5 h / Heating View Scheme

1: 54 percent / Br2 / CCl4; CH2Cl2 / 0.08 h / Ambient temperature 2: 98 percent / K2CO3 / acetone / 1.5 h / Heating 3: 55 percent / dimethylformamide / 2 h / Heating View Scheme