3-Alpha-羟基-6-氧代-5-alpha-24-胆烷酸甲酯3-乙酸盐合成路线 （共 6 条）
参考文献
SAGE THERAPEUTICS, INC.; UPASANI, Ravindra, B.; HARRISON, Boyd, L.; ASKEW, Benny, C. Jr.; DODART, Jean-Cosme; SALITURO, Francesco, G.; ROBICHAUD, Albert, J.
Patent: WO2013/36835 A1, 2013 ;
Location in patent: Page/Page column 178; 179; 180 ;
反应条件
1: chromium (VI)-oxide; aqueous acetic acid 3: Chromatographieren einer Loesung in Benzol an (alkalihaltigem) Aluminiumoxid View Scheme
参考文献
SAGE THERAPEUTICS, INC.; UPASANI, Ravindra, B.; HARRISON, Boyd, L.; ASKEW, Benny, C. Jr.; DODART, Jean-Cosme; SALITURO, Francesco, G.; ROBICHAUD, Albert, J.
Patent: WO2013/36835 A1, 2013 ;
反应条件
2: Chromatographieren einer Loesung in Benzol an (alkalihaltigem) Aluminiumoxid View Scheme
参考文献
SAGE THERAPEUTICS, INC.; UPASANI, Ravindra, B.; HARRISON, Boyd, L.; ASKEW, Benny, C. Jr.; DODART, Jean-Cosme; SALITURO, Francesco, G.; ROBICHAUD, Albert, J.
Patent: WO2013/36835 A1, 2013 ;
反应条件
1: sulfuric acid / |Reflux 2: Jone's reagent / acetone / 0.5 h / 0 °C 3: hydrogenchloride / water; methanol / 20 °C 4: pyridine / 70 °C View Scheme
参考文献
SAGE THERAPEUTICS, INC.; UPASANI, Ravindra, B.; HARRISON, Boyd, L.; ASKEW, Benny, C. Jr.; DODART, Jean-Cosme; SALITURO, Francesco, G.; ROBICHAUD, Albert, J.
Patent: WO2013/36835 A1, 2013 ;
反应条件
1: diazomethane; diethyl ether; methanol 2: pyridine View Scheme
参考文献
Fernholz
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1935 , vol. 232, p. 202,204
参考文献
Hoehn; Linsk; Moffett
Journal of the American Chemical Society, 1946 , vol. 68, p. 1855
