2-氨基-3-溴-5-氯吡啶合成路线 （共 15 条）
反应条件
1: hydrobromic acid; bromine; sodium nitrite / H2O / -5 - 60 °C
2: 9.7 g / sodium iodide; chlorotrimethylsilane / various solvent(s) / 0.75 h / Heating
View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
Tetrahedron, 2004 , vol. 60, # 51 p. 11869 - 11874
反应条件
1: hydrobromic acid; bromine; sodium nitrite / H2O / -5 - 60 °C
2: 9.7 g / sodium iodide; chlorotrimethylsilane / various solvent(s) / 0.75 h / Heating
3: 69 percent / potassium fluoride; cuprous iodide; N-methylpyrrolidinone / Heating
View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
Tetrahedron, 2004 , vol. 60, # 51 p. 11869 - 11874
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in DMF (N,N-dimethyl-formamide)
T=120°C; 0.5 h; Microwave heating;
参考文献
ASTRAZENECA AB
Patent: WO2005/111001 A1, 2005 ;
Location in patent: Page/Page column 56; 57 ;
WO 2005/111001 A1
反应条件
acetic acid in 1-methyl-pyrrolidin-2-one; water
参考文献
Haley, Gregory J.; Barnes, Keith D.; Wood, William W.; Hu, Yulin; Cuccia, Salvatore; Cotter, Henry Van Tuyl; Gypser, Andreas; Schwogler, Anja
Patent: US2003/83311 A1, 2003 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); K4[Fe(CN)6] trihydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene in water; tert-butyl alcohol
T=120°C; P=8274.59 Torr; 0.166667 h; Microwave irradiation;
参考文献
Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; Schwarcz, Robert; Costantino, Gabriele
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9482 - 9495
